Galpharm Treathay Hayfever Relief Fexofenadine, 30 Count (Pack of 1)

Product Information

Limited animal studies do not indicate direct or indirect harmful effects with respect to effects on pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5.3) . TREATHAY 120 mg tablets should not be used during pregnancy unless on the advice of a doctor. There are no data on the content of human milk after administering fexofenadine hydrochloride. However, when terfenadine was administered to nursing mothers fexofenadine was found to cross into human breast milk. Therefore TREATHAY 120 mg tablets is not recommended for mothers breast-feeding their babies. Breast-feeding women should only use TREATHAY 120 mg tablets if advised to do so by a doctor. If your doctor or health visitor says your baby is healthy, you can take fexofenadine while breastfeeding. Fexofenadine does not undergo hepatic biotransformation and therefore will not interact with other medicinal products through hepatic mechanisms. Fexofenadine is a P-glycoprotein (P-gp) and organic-anion-transporting polypeptide (OATP) substrate. Concomitant use of fexofenadine with P-gp inhibitors or inducers can affect the exposure to fexofenadine. Coadministration of fexofenadine hydrochloride with P-gp inhibitors erythromycin or ketoconazole has been found to result in a 2-3 times increase in the level of fexofenadine in plasma. The changes were not accompanied by any effects on the QT interval and were not associated with any increase in adverse reactions compared to the medicinal products given singly. In a five-way crossover study with 10 healthy volunteers, 1<4-strength grapefruit juice, grapefruit juice, orange juice and apple juice (300 mL with drug administration and 150 mL every 1<2 hour for up to 3 hours, total volume 1.2 L) reduced the mean area under the plasma concentration-time curve (AUC) of a 120 mg dose of fexofenadine by 23%, 67%, 72% and 77%, respectively, compared to water.

Fexofenadine hydrochloride was found to be non-mutagenic in various in vitro and in vivo mutagenicity tests. Dizziness, drowsiness, fatigue and dry mouth have been reported with overdose of fexofenadine hydrochloride. Single doses up to 800 mg, and doses up to 690 mg twice daily for 1 month, or 240 mg once daily for 1 year have been administered to healthy subjects without the development of clinically significant adverse reactions as compared with placebo. The maximum tolerated dose of fexofenadine hydrochloride has not been established. The active substance is fexofenadine hydrochloride. Each film-coated tablet contains 120 mg of fexofenadine hydrochloride, which is equivalent to 112 mg of fexofenadine But fexofenadine seems to be less likely to make you feel sleepy than other non-drowsy antihistamines. The recommended dose of fexofenadine hydrochloride for adolescents aged 12 years and over is 120 mg once daily taken before a meal.

Precaution

feeling sleepy – try a different non-drowsy antihistamine. If this does not help, talk to your doctor. In adults, the following undesirable effects have been reported in post-marketing surveillance. The frequency with which they occur is not known (can not be estimated from available data) Dizziness, drowsiness, fatigue and dry mouth have been reported with overdose of fexofenadine hydrochloride. Single doses up to 800 mg, and doses up to 690 mg twice daily for 1 month, or 240 mg once daily for 1 year have been administered to healthy subjects without the development of clinically significant adverse reactions as compared with placebo. The maximum tolerated dose of fexofenadine hydrochloride has not been established. Try to take fexofenadine tablets at about the same time every day. Choose a time that is easy to remember. If any of these apply to you, or if you are not sure, tell your doctor or pharmacist before taking this medicine.

Anti Malaria Malaria is a serious tropical disease spread by mosquitoes. If it isn’t diagnosed and treated promptly, it can be fatal. A single mosquito bite is all it takes for someone to become infected. Symptoms of malaria It’s important to be aware of the symptoms of malaria if you’re travelling to areas where there’s a high risk of the disease. Symptoms include: 1. A high temperature of 38C or above 2. Feeling hot and shivery 3. Headaches 4. Vomiting 5. Muscle pains 6. Diarrhoea Symptoms usually appear between 7 and 18 days after becoming infected, but in some cases the symptoms may not appear for up to a year, or occasionally even longer. When to seek medical attention Seek medical help immediately if you develop symptoms of malaria during or after a visit to an area where the disease is found. You should still seek medical help even if it’s several weeks, months or a year after you return from travelling. If there’s a possibility you have malaria, a blood test will be carried out to confirm whether or not you’re infected. You should receive the results of your blood test on the same day. If you have malaria, treatment will… Avoid fruit juice. Fruit juices like grapefruit, orange, and apple may reduce bioavailability and overall exposure to the medication.The H 1 histamine receptor is responsible for mediating hypersensitivity and allergic reactions. Exposure to an allergen results in degranulation of mast cells and basophils, which then release histamine and other inflammatory mediators. Histamine binds to, and activates, H 1 receptors, which results in the further release of pro-inflammatory cytokines, such as interleukins, from basophils and mast cells. These downstream effects of histamine binding are responsible for a wide variety of allergic symptoms, such as pruritus, rhinorrhea, and watery eyes. There's very little information about taking herbal remedies and supplements with fexofendadine. There might be a problem taking some herbal remedies and supplements with it, especially ones that cause sleepiness or a dry mouth, or make it difficult to pee.

Fexofenadine at concentrations 32 times greater than the therapeutic concentration in man had no effect on the delayed rectifier K+ channel cloned from human heart. You may only need to take it as a one-off dose or for a day or two, for example if you have a reaction to an insect bite.Fexofenadine is not suitable for some people. To make sure it's safe for you, tell your doctor or pharmacist before taking fexofenadine if you: Human histamine wheal and flare studies following single and twice daily doses of fexofenadine hydrochloride demonstrate that the medicinal products exhibits an antihistaminic effect beginning within one hour, achieving maximum at 6 hours and lasting 24 hours. There is no evidence of tolerance to these effects after 28 days of dosing. A positive dose-response relationship between doses of 10 mg to 130 mg taken orally was found to exist. In this model of antihistaminic activity, it was found that doses of at least 130 mg were required to achieve a consistent effect that was maintained over a 24 hour period. Maximum inhibition in skin wheal and flare areas was greater than 80%. Clinical studies conducted in seasonal allergic rhinitis have shown that a dose of 120 mg is sufficient for 24 hour efficacy. There are no data on the content of human milk after administering fexofenadine hydrochloride. However, when terfenadine was administered to nursing mothers fexofenadine was found to cross into human breast milk. Therefore TREATHAY 120 mg tablets is not recommended for mothers breast-feeding their babies. Breast-feeding women should only use TREATHAY 120 mg tablets if advised to do so by a doctor. Dogs tolerated 450 mg/kg administered twice daily for 6 months and showed no toxicity other than occasional emesis. Also, in single dose dog and rodent studies, no treatment-related gross findings were observed following necropsy. You may only need to take fexofenadine on a day you have symptoms, such as when you've been exposed to something you're allergic to, like animal hair.