New Medical section on G protein coupled receptors (GCPRs) discusses the range of diseases for which drugs target GPCRs Lehninger Principles of Biochemistry, 8e continues to help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new co-author Aaron Hoskins have focused this eighth edition around the fundamental principles to help students understand and navigate the most important aspects of biochemistry. Text features and digital resources in the new Achieve platform emphasize this focus on the principles, while coverage of recent discoveries and the most up-to-date research provide fascinating context for learning the dynamic discipline of biochemistry. Interactive Metabolic Map allows students to navigate and zoom between overviews and detailed views of the most commonly taught metabolic pathways. Embedded Tours take students through the pathways step-by-step, helping them to both visualize concepts in isolation and understand how concepts are connected. By examining the pathways in this way, students are better equipped to understand the meaning of those connections. Assessment questions help students solidify their understanding and provide more structure to their learning. *Metabolic Pathways include: glycolysis, gluconeogenesis, the citric acid cycle, oxidative phosphorylation, the pentose phosphate pathway, fatty acid synthesis, the urea cycle, and β oxidation.

Synthases and Synthetases; Ligases and Lyases; Kinases,Phosphatases, and Phosphorylases: Yes, the Names Are Confusing! Interactive Molecular Figures allow students to view and interact with textbook illustrations of protein structures online in interactive 3-D models for a better understanding of their three-dimensional structures.More than 600 end-of-chapter problems (all available in Achieve) give students further opportunity to practice what they have learned. An interactive e-book with embedded multimedia and features for highlighting, note-taking and accessibility support In-text Worked Examples take students through particular difficult equations to improve their quantitative problem-solving skills. This text has an emphasis on problem solving with in text ‘Worked Examples’ that take students through particular difficult equations to improve their quantitative problem-solving skills, and data ‘Analysis Problems’ that encourage students to synthesize what they have learned and apply their knowledge to the interpretation of data from the literature. More than 600 end-of-chapter problems (all available in Achieve) are also included to give students further opportunity to practice what they have learned.

Chemical Logic Figures highlight the conversation of mechanisms and illustrate patterns that make learning pathways easier. (Provided for each of the central metabolic pathways) The new edition brings this remarkable text into a new era. Like its predecessors, Lehninger Principles of Biochemistry, Sixth Edition strikes a careful balance of current science and enduring concepts, incorporating a tremendous amount of new findings, but only those that help illustrate biochemistry’s foundational principles. With this edition, students will encounter new information emerging from high throughput DNA sequencing, x-ray crystallography, and the manipulation of genes and gene expression, and other techniques. In addition, students will see how contemporary biochemistry has shifted away from exploring metabolic pathways in isolation to focusing on interactions among pathways. They will also get an updated understanding of the relevance of biochemistry to the study of human disease (especially diabetes) as well as the important role of evolutionary theory in biochemical research.

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A flexible suite of resources to support learning core concepts, visualization, problem-solving, and assessment. New medical section on the role of polyunsaturated fatty acids and trans fatty acids in cardiovascular disease Tools for understanding are provided including ‘Key Conventions’ and ‘Special Themes’ (Metabolic Integration, Obesity, and Diabetes, Evolution) as well as ‘Medical Insights and Applications-Icons’ used throughout the book denote material of special medical interest and updated to reflect the most current content.