Having enough litter boxes for the number of cats in your home is essential. The general rule of thumb is to have one litter box per cat plus one extra. To help you find the best pet stain removers on the market, we tested 16 different pet stain removers and assessed them on ease of use, odor elimination, scent, and effectiveness. We also interviewed Dr. Whitney Miller, the Chief Veterinarian at Petco, and Vera Peterson, President of Molly Maid, a Neighborly company, for additional guidance on choosing the best pet stain removers. An enzyme cleaner is a cleaning solution that uses enzymes to break down and remove stains and odors. Enzyme cleaners clean pet stains, food stains, and other types of messes. These cleaners break down the proteins and other organic materials that cause stains and odors. EXTREMELY EFFECTIVE - Simple Solution Spring Breeze Extreme Stain and Odor Remover is 3 times stronger than our regular stain and odor remover, eliminating the toughest dog and cat messes faster.

Our experts also like that this cleaner is pet and kid-friendly, as it’s made with natural ingredients and doesn’t contain any harsh chemicals. This cleaner is also eco-friendly and safe on multiple surfaces and fabrics. You can even use it on your car upholstery or laundry to remove pet stains and odors from clothing. This enzymatic cleaner is biodegradable, so you can feel good about using it around your home. It also contains no harsh chemicals or toxins, and the essential oils give it a refreshing spring mint scent. What we love about this cleaner is that it’s multipurpose. Not only can you use it on carpets and upholstery, but you can also use it on clothing, pet beds, and other fabrics. Additionally, the Spruce Pet Stain & Odor Remover is free of dyes, caustics, synthetic fragrances, phthalates, parabens, chlorine, formaldehyde, triclosan, or phosphates. This makes it a safe choice for households with children or pets.We also sprayed them on fabrics and let them sit for a few minutes to see if they would remove the cat urine smell.

Nature’s Miracle is a favorite of Dr. Miller, who told us the brand’s enzymatic cleaners are a great choice to safely remove pet stains and odors. One tester was so pleased with its effectiveness that they wished they knew about the product sooner. “I felt like I lost the battle with cat pee, but this [product] is giving me renewed hope I can salvage the carpet in my house that I thought my cat had ruined!” they said. While this product worked fast on fresh stains and smells, it wasn’t as effective on set-in stains. We only noticed a difference after several applications and a bit of scrubbing, but the set-in stains never fully vanished. Therefore, we recommend this product if you’re looking for a product that will get to work immediately on newer stains.It’s important to note that you’ll usually need to use an enzymatic cleaner more than once to eradicate the stain and odor. So, don’t get discouraged if you don’t see results after the first application. What Enzyme Breaks Down Cat Urine? Cats are clean creatures, and they prefer a clean litter box. If the litter box is dirty, your cat may be reluctant to use it. Make sure to scoop the litter box daily and change the litter completely at least once a week. If you have more than one cat, you may need to clean the litter box more often. Provide Enough Litter Boxes Stains can be stubborn, especially if they’ve been around for a while. Old stains may require multiple applications of enzyme cleaner before they disappear entirely. New stains will usually disappear after one or two applications. For those looking for a fast-acting but affordable carpet cleaner, SHOUT’s Carpet Stain Remover and Odor Eliminator Spray is the best choice. This powerful spray removes pet stains and eliminates odors in under 10 minutes, making it the fastest stain remover on our list. This powerful pro-bacteria and enzyme formula is also great for preventing repeat marking. So if your dog or cat tends to pee in the same spot, this cleaner will help discourage them from going there again. What We Liked

This pet stain remover can handle messes such as urine, feces, blood, and mud, as well as grease and even wine stains. It’s compatible on carpet, rugs, tile, upholstery, bedding, clothing, and any surface that is porous and water-safe. What’s more, with every bottle that is bought, the brand in turn provides food for a rescue animal in need. We tested this cleaner on various surfaces, including carpet, upholstery, hardwood floors, and tile. It worked great on all of them, with no adverse effects. The one caveat is that you should avoid using it on light-colored fabrics, as it may cause them to discolor. And if you’re using it on hardwoods or tiles, mix it with water first. ERASE ODORS AND STAINS - Discourage repeat marking with our professional-strength Pro-Bacteria™ and enzyme formula, which breaks down and eliminates stains and odors, leaving behind a refreshing Spring Breeze scent. When looking for the best enzyme cleaner for cat urine, you’ll want to ensure that the active ingredients effectively break down stains and odors. Recommended uses: For carpets, rugs, car upholstery, mattress, furniture, pet beds, concrete floor, tileThis eco-friendly pet stain remover from Biokleen has a B rating from the Environmental Working Group (EWG), and is one of the few products on our list that has been evaluated and received high marks. It’s made of biodegradable ingredients, making it great for people who prefer to keep cleaning products that contain phosphates, chlorine, ammonia, brighteners, or artificial fragrances out of their home. Simple Solution Yard Odor Away! Hose Spray Concentrate is an excellent value for the money. Its price point is very reasonable, especially considering how much product you get. And it does an excellent job of eliminating cat urine odor from your yard. What We Liked

Whether fresh or set in, SHOUT’s Carpet Stain Remover and Odor Eliminator Spray can handle it. However, we recommend using this cleaner on fresh stains as soon as possible for the best results. You may need to spray and blot several times to remove set-in stains. What We Liked Choose a quiet area of the house for the litter box, and make sure it’s not near a busy room or loud appliances. In addition to urine, this pet stain remover is also able to clean up vomit, feces, drool, and more on carpets, hardwood floors, furniture, and fabrics. It also contains a light citrus scent that further helps with masking stain odors. While this specific product is made with cats in mind, Nature’s Miracle also sells a dog version. For heavier stains, we recommend pre-treating the area with this cleaner. Just spray the cleaner on the stain and let it sit for 5 to 10 minutes before blotting it up with a clean cloth. If the color is still visible, you can repeat the process until it disappears. Most enzymatic cleaners also contain surfactants, chemicals that lower the surface tension of water, allowing it to penetrate surfaces more easily.When choosing an enzyme cleaner, you’ll want to ensure that it’s labeled color safe. To be sure, you can also test the cleaner on an inconspicuous area of the fabric or carpet. Ease of Application