Kautio AL, Haanpaa M, Kautiainen H, Kalso E, Saarto T (2011) Burden of chemotherapy-induced neuropathy – a cross-sectional study. Support Care Cancer 19:1991–1996 Ikeda I, Yamashita Y, Ono T, Ogawa H (1994) Selective phototoxic destruction of rat Merkel cells abolishes responses of slowly adapting type I mechanoreceptor units. J Physiol 479(Pt 2):247–256

Fagan BM, Cahusac PM (2001) Evidence for glutamate receptor mediated transmission at mechanoreceptors in the skin. Neuroreport 12:341–347 Basbaum AI, Bautista DM, Scherrer G, Julius D (2009) Cellular and molecular mechanisms of pain. Cell 139:267–284 Yamashita Y, Akaike N, Wakamori M, Ikeda I, Ogawa H (1992) Voltage-dependent currents in isolated single Merkel cells of rats. J Physiol 450:143–162 Sang CN, Gracely RH, Max MB, Bennett GJ (1996) Capsaicin-evoked mechanical allodynia and hyperalgesia cross nerve territories. Evidence for a central mechanism. Anesthesiology 85:491–496Ikeda R, Cha M, Ling J, Jia Z, Coyle D, Gu JG (2014) Merkel cells transduce and encode tactile stimuli to drive Abeta-afferent impulses. Cell 157:664–675 Findlater GS, Cooksey EJ, Anand A, Paintal AS, Iggo A (1987) The effects of hypoxia on slowly adapting type I (SAI) cutaneous mechanoreceptors in the cat and rat. Somatosens Res 5:1–17 Kernan M, Cowan D, Zuker C (1994) Genetic dissection of mechanosensory transduction: mechanoreception-defective mutations of Drosophila. Neuron 12:1195–1206 Diamond ME, von Heimendahl M, Knutsen PM, Kleinfeld D, Ahissar E (2008) ‘Where’ and ‘what’ in the whisker sensorimotor system. Nat Rev Neurosci 9:601–612 Barton DL, Wos EJ, Qin R, Mattar BI, Green NB et al (2011) A double-blind, placebo-controlled trial of a topical treatment for chemotherapy-induced peripheral neuropathy: NCCTG trial N06CA. Support Care Cancer 19:833–841

PORTABLE SENSORY EXPERIENCE: A portable sensory tactile experience that may ease anxiety and stress. Each disc features a different texture that can calm the body and mind creating moments of mindfulness throughout the day at school, at-home, or on-the-go! Zimmerman A, Bai L, Ginty DD (2014) The gentle touch receptors of mammalian skin. Science 346:950–954 Press D, Mutlu S, Guclu B (2010) Evidence of fast serotonin transmission in frog slowly adapting type 1 responses. Somatosens Mot Res 27:174–185 Munger BL (1965) The intraepidermal innervation of the snout skin of the opossum. A light and electron microscope study, with observations on the nature of Merkel’s Tastzellen. J Cell Biol 26:79–97

Yoshimura M, Jessell T (1990) Amino acid-mediated EPSPs at primary afferent synapses with substantia gelatinosa neurones in the rat spinal cord. J Physiol 430:315–335 Hama A, Takamatsu H (2016) Chemotherapy-induced peripheral neuropathic pain and rodent models. CNS Neurol Disord Drug Targets 15:7–19 We’ve been playing with it for a few days now. Everyone loves the varied sensory experience as you walk from piece to piece. It’s sort of like an ever changing foot massage. Woo SH, Lumpkin EA, Patapoutian A (2015) Merkel cells and neurons keep in touch. Trends Cell Biol 25:74–81

WHAT YOU GET (SIZE/DIMENSIONS/COLORS): 6 Tactile Sensory Discs each approximately 5 inches ibn diameter featuring calming textures soft mop, flip-sequins, squishy sponge, colorful sand, colorful beads with hidden letters, and colorful balls with hidden shapes. Fukuda J, Ishimine H, Masaki Y (2003) Long-term staining of live Merkel cells with FM dyes. Cell Tissue Res 311:325–332 Carvell GE, Simons DJ (1990) Biometric analyses of vibrissal tactile discrimination in the rat. J Neurosci 10:2638–2648 newcommand{\vecs}[1]{\overset { \scriptstyle \rightharpoonup} {\mathbf{#1}}}\) \( \newcommand{\vecd}[1]{\overset{-\!-\!\rightharpoonup}{\vphantom{a}\smash{#1}}} \)\(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\) \(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\)\(\newcommand{\AA}{\unicode[.8,0]{x212B}}\)

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Woo SH, Ranade S, Weyer AD, Dubin AE, Baba Y et al (2014) Piezo2 is required for Merkel-cell mechanotransduction. Nature 509:622–626 My favorite piece is the red one, because the large rods really dig into my soles. With enough time, I walk away feeling refreshed not only in my feet but also in my lower legs. That’s a plus, especially given that I have #plantarfasciitis. Merkel F (1875) Tastzellen and Tastkoerperchen bei den Hausthieren und beim Menschen. Arch Mikroscop Anat 11:636–652 Tachibana T, Nawa T (2002) Recent progress in studies on Merkel cell biology. Anat Sci Int 77:26–33 Albers J, Chaudhry V, Cavaletti G, Donehower R (2007) Interventions for preventing neuropathy caused by cisplatin and related compounds. Cochrane Database Syst Rev 24:CD005228