Although myoinositol is the most abundant inositol isoform, another stereoisomer with great therapeutic qualities is D-chiro-inositol (DCI) [44]. By supporting your body’s hormone rhythms, this fertile supplement can help with metabolism, energy, bloating, skin health, and more. Finally, MI was able to significantly increase SHBG levels only after at least 24 weeks of administration (standardized mean difference = 0. GMO-Free and Made without Gluten, Yeast, Dairy, Soy, Artificial Colors, or Artificial Preservatives. Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice.

A recent meta-analysis [ 26] evaluated the efficacy of treatments with MI, alone or combined with DCI (40 : 1 ratio of MI : DCI) for 12–24 weeks, in nine RCTs comprising 247 cases and 249 controls [ 19, 20, 22, 27– 32]. In addition, we have to consider that the intestinal absorption of myo-inositol is reduced by the simultaneous administration of D-chiro-inositol since the two stereoisomers compete with each other for the same transporter that has similar affinity for each of them. Nevertheless, when DCI is administered at a high dosage and achieves higher concentrations it is able to compete with MI.Several follow-up studies supported these findings and the idea that MI exerts beneficial effects on ovulation and oocyte quality [ 19– 22].

A study published in 2019 concluded that people with PCOS have a two-fold higher risk of developing GD than those without PCOS.Both products are designed to support ovulation and aid fertility in women who have been diagnosed with PCOS or who struggle with irregular cycles.