All FDA-approval fillers have been studied and proven safe and effective when injected into specific areas of the face or hands by a licensed medical professional.

the particle source 11 whilst suitable for use in the laboratory, would not be particularly well suited to commercial use because the powder to be delivered could become contaminated and/or fall out of the reservoir provided in the particle source cassette. If you’ve had a needle-free filler and developed a side effect, it’s best to get checked by a medical doctor like a board-certified dermatologist.When 30 bar driver pressure is used, this corresponds to a pressure difference of 6 bar which serves to draw the particles into the flow.

It would be advantageous to have a needless syringe which operates quietly and in which the particles may be spread over a larger target area, with a reasonably uniform distribution over that target area. the gas is first brought to Mach 1 in the throat and the downstream divergence accelerates it to a steady state supersonic speed.They inject the filler with a needle, which allows them to place the right amount of filler where it’s needed and without force. and it has been found that the transsonic gas jet formed effectively entrains the particles such that they are uniformly distributed in the gas flow. the nozzle has a divergent downstream section, it has been found that by extending the length of the nozzle to increase the diameter of the nozzle at its downstream exit, significantly larger target areas on the skin or mucosa may be penetrated by the particles, with good uniformity of distribution across the larger target area. the bursting of the rupturable membrane can make operation of the syringe fairly noisy, which can be a disadvantage when treating small children for example. Such filters have an upper limit to gas velocity through the filter so as to ensure that they operate to the specification.

has been developed in which a short parallel section 16 is followed by a divergent section 17 which in turn is followed by a parallel section 65 . The syringe includes a convergence which reduces pressure of the gas flowing in the gas flow path due to the Venturi effect such that particles initially located outside of the gas flow path are drawn into the gas flow path under the action of the reduced pressure and become entrained in the gas. the above embodiments all utilize a first convergence 5 , 5 ′ to create a reduced pressure region which can be used to draw the particles into the gas flow path. a closed gas cylinder containing a single dose of gas sufficient for a single needleless injection may be provided.

the bore 3 of the nozzle is substantially parallel-sided, apart from a short taper at its upstream end. A variation in particle velocity can make it difficult to deliver high-potency powdered drugs, vaccines etc to specific target layers within the skin. Said particles may, for example, comprise a drug, vaccine, diagnostic agent or carrier particle coated with a genetic material (or any combination thereof). This is the earliest documented jet injector to administer water or medicine under enough pressure to penetrate the skin without the use of a needle. the “fast expand” nozzle may be used to replace the nozzle of any of the previously described embodiments.

g. using a spanner or manually operating a lever built into the plug 52 ) by approximately 45° such that, although the powder cavity 55 is in the same plane as all three of the holes 53 , 54 , it is not in communication with any of them (see FIG. the flat, main downstream face 6 of the sonic nozzle 4 is spaced upstream from the upstream face 7 of nozzle 2 . A61M5/00— Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e. Marshall Lockhart, an engineer, filed a patent for his idea of a jet injector after learning of Sutermeister's invention.

mm, the good spread of the particles across a target area substantially equal to the area of the nozzle bore 3 at the nozzle exit 2 will be appreciated. The ratio of flow cross-sections between the first and second convergences 5, 9 is relevant to the functioning of the syringe. However, the World Health Organization no longer recommends jet injectors for vaccination due to risks of disease transmission. Alternatively, a closed gas cylinder containing a single dose of gas sufficient for a single needleless injection may be provided. a spacer 35 Provided on the downstream end of the nozzle 31 is a spacer 35 , whose downstream face is intended to be placed against the skin or mucosa surrounding the target area to space the nozzle's downstream exit face 36 from the target area.