In a world full of pollution, processed foods, sugar, pharmaceuticals, too much time indoors and not enough access to high quality air or high nutrient foods, it can be a struggle for the body to work as optimally as it could. Add to that a lifestyle filled with stress-inducing deadlines, work schedules, relationship issues and financial instability. It’s no wonder our gut health definitely isn’t as vibrant and healthy as it could be. Venkataraman R, Shenoy R, Ahire JJ, Neelamraju J, Madempudi RS. Effect of Bacillus coagulans Unique IS2 with Lactulose on Functional Constipation in Adults: a Double-Blind Placebo Controlled Study. Probiotics Antimicrob Proteins 2021. View abstract. Yeah. So thank God we’re in this era of microbiome research because we know now from many, many studies from many different strains of probiotics, all the beneficial effects that they have and we’re still learning more and how to develop more and better probiotics. So we’re growing fast in this knowledge base. But probiotics essentially are modulators of intestinal function, so they will change the immune function. They’ll change the cell signaling communications. They’ll compete with other bacteria that are bad bugs and get rid of those. They’ll compete with yeast and help reduce those by actually helping promote more of the good bugs. There were no pre-clinical toxicity studies provided for the B. coagulans strain MTCC 5856 spore preparation specifically, however published pre-clinical studies for other B. coagulans strains showed an overall low acute toxicity.

Absolutely. I think historically we didn’t have refrigerators, and as a species, we really got good at preserving food. And we did that through making cheese or through drying meat or through creating fermented foods. And these cultures have had these for thousands of years. Following the fermentation, the culture is centrifuged to separate the biomass from the medium. The biomass of bacterial spores is filtered through a sterile stainless steel 100 mesh filter, and then spray-dried at high temperatures (up to 115 °C) for 2 hours. The resulting powder is combined with food grade maltodextrin to obtain commercial formulations of three different concentrations of B.coagulansMTCC 5856 spores (LactoSpore® 6 billion CFU/g, LactoSpore® 15 billion CFU/g, and LactoSpore® 100 billion CFU/g). Yeah,, yeah. So first of all, cytokines, we’ve heard about in the face of COVID and the cytokines storm, which kills people, essentially it’s a flood of these inflammatory molecules. And cytokines are the messenger molecules of your immune system and they have all kinds of names. One class of them are called interleukins, and there’s many, many different kinds. Some are anti-inflammatory, some are inflammatory. Interleukin six particularly is a very common one that’s very high in belly fat and visceral fat, abdominal fat. It’s quiet correlated with heart disease, dementia, cancer, obesity, diabetes, and it’s really driven off of a state of low grade inflammation that comes from this visceral or belly fat on fire. Our LactoSpore® tablets are an ideal nutritional supplement for anyone who wants a convenient daily tablet to up their intake of probiotics. Benefits Based on the data provided, there are no nutritional safety concerns with the food use of LactoSpore®. 7.Toxicological Assessment

While gut health is a primary focus, Lactospore's benefits extend beyond the digestive system. 1. Immune System Support CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Britton RA, Versalovic J. Probiotics and gastrointestinal infections. Interdiscip Perspect Infect Dis. 2009;2008:1–10. Lactospore is a powerful probiotic strain with significant potential to improve gut health and overall wellness. Its ability to survive harsh conditions and provide a range of benefits, from enhancing gut barrier function to supporting immune and mental health, makes it

Yeah, we’re getting there. I think there’s sometimes overreach and over promising and under delivering on some of these tests, and they don’t take in the context of patient’s overall health, the other parts of their digestive function. They just look at the actual bacteria and they make all these conclusions based on the science. But that can be a lot of noise too and not actually helpful for people. So I think it’s important to learn about yourself, to do the testing, but take it with a grain of salt. A lot of the recommendations that are happening now, you want to try stuff and see how it works, but you don’t want to think of it as the gospel. Bacillus coagulans MTCC 5856 has been marketed as a dietary ingredient, but its efficacy in diarrhea predominant irritable bowel syndrome (IBS) condition has not been clinically elucidated till date. Thus, a double blind placebo controlled multi-centered trial was planned to evaluate the safety and efficacy of B. coagulans MTCC 5856 in diarrhea predominant IBS patients. MethodsGill H, Prasad J. Bioactive components of milk: probiotics, immunomodulation, and health benefits. In: Bosze Z, editor. Advances in experimental medicine and biology. New York: Springer; 2008. p. 423–64.

Liu, Y., Fatheree, N. Y., Mangalat, N., & Rhoads, J. M. (2012). Human-derived probiotic Lactobacillus reuteri strains differentially reduce intestinal inflammation. American Journal of Physiology-Gastrointestinal and Liver Physiology, 299(5), G1087-G1096.A bacterial reverse mutation assay and clinical toxicity studies for B. coagulans strain MTCC 5856 spore preparation were examined. The results of the Ames test (OECD Test No. 471) performed with LactoSpore® did not show any mutagenic activity. Additional published toxicological studies for B. coagulans indicate no mutagenic, clastogenic, or genotoxic effects. For thousands of years, ancient health and wellbeing systems have known that healthy digestion is the key to a healthy body and healthier overall life. Taken together, the NOAEL of 1948 mg/kg per day (equivalent to 134 x 10 9 CFU/kg bw/day) established in the 1-year dietary study in rats, and the Estimated Daily Intake (EDI) for B. coagulans MTCC 5856 of 36.4 x 10 9 CFU per day (equivalent to 0.52 x 10 9 CFU/kg bw per day for an individual weighing 70 kg), the margin of exposure (MOE) of LactoSpore® is estimated to be 258.